Primobolan Depot is one of the oldest anabolic steroids on the market today. First brought to market by Organon in 1962, it has spanned five decades as a popular anabolic steroid. While its popularity has diminished over the years, many still find value in this compound. Its mild nature helps make it an appealing choice for many individuals. However, although the compound is mild in nature it does carry some risks and side effects that must be understood prior to use. Furthermore, if we look at how this steroid was used during its heyday we can get a better understanding of how it works, what you can expect from it, and more important than anything else…how to keep yourself safe. It’s only by taking these things into consideration that one can make an informed decision about whether or not this medication is right for them.

Side effects

Side effects

The primary concern associated with Primo use is hepatotoxicity (liver toxicity). Many steroids can cause liver damage including Dianabol but primo has a reputation for being particularly harsh on the liver. This is due to the fact that it is a c17-alpha alkylated steroid. When this modification occurs the half-life of the hormone is extended by allowing it to survive the first pass through your liver. Because of this, if you are going to use primo then you must take great care with its use and monitor liver enzyme levels closely. If you are not willing to do this then do not consider using primo as it can cause extensive damage including possible failure. The good news is that there are some steps you can take which may help minimize or even eliminate any risk for damage:

First, ensure you follow all dosing guidelines precisely. Never exceed recommended dosages and try to space out injections so there’s at least 1/2 a day in between. Also, you must be committed to following proper post-cycle therapy (PCT) protocol. This means you need a SERM such as Nolvadex and/or HCG at the conclusion of your steroid cycle—even if it is long after all signs of steroids have vanished from your body.

Do not drink alcohol during a cycle. If consumed, do so in moderation and always with food.

Finally, you must understand that all steroids have side effects but some are worse than others. In the case of Primobolan Depot, it is the mildest steroid on the market today—but even so, precautions must be taken to ensure your safety while using it.

What kind of diet should I follow during the cycle?

Another area of concern is the steroid’s ability to aromatize into estrogen. Remember, this means it can cause water retention and fat gain. If you are prone to these conditions then it may be best not to use Primo for this reason. However, if you are willing to accept some water retention while on cycle (and which you should) then simply ensure your diet is low in carbs and sodium during the cycle—you’ll likely lose most of that water in 3-4 weeks post-cycle by following a conservative diet.

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How should I take it?

Primobolan Depot is injected daily when using a moderate dose. When using this steroid to kick start your cycle, the total duration of use will be no longer than 4-5 weeks. You can also use it at the conclusion of your cycle to help you quickly recover your natural testosterone levels—this way you have no excuse for missing workouts due to low testosterone! Regardless of how you choose to use Primo if you do decide to run it remember that no more than 500mg/week is all that’s needed. If more is desired then consider stacking it with another mild anabolic like Deca or Equipoise. However, keep in mind any time you add another compound there are additional side effects so be mindful of your health and stay safe.

How does it compare to other steroids?

Primobolan Depot is a favorite steroid among many for several reasons: First, there’s little worry about estrogenic side effects; this makes it great for women and men who are sensitive to the hormone. Second, it’s not hepatoxic (liver toxic), which can make other steroids like Anadrol difficult to use for extended periods of time without risk of liver damage. Finally, there’s very little water retention or aromatization with Primo so you needn’t worry about getting puffy or retaining too much water weight—this means you won’t have to run an anti-estrogen! Because of these traits, Primobolan Depot can be an excellent steroid to consider when you’re trying to grow without the typical side effects. Other steroids that are often stacked with Primobolan Depot include Testosterone Cypionate, Equipoise, Deca Durabolin, and Anavar for men; also Winstrol if your primary goal is gaining strength and/or athletic performance. For women, Primo comes in handy during “bulking” phases of training where they simply need more calories—Trenbolone being a good choice but not always well-tolerated by women. How does it stack up against human growth hormone (HGH)?

Primobolan Depot stacks up well against HGH in all regards. Like many steroids, it’s often combined with HGH during “bulking” phases to promote faster muscle building while also helping an athlete retain lean tissue at the same time. However, keep in mind you should not combine Primo with more than one steroid at a time. Doing so is asking for trouble and there can be harsh consequences when stacked together too much. Remember to always stack only two or less anabolics together—especially oral types like Anadrol and Dianabol/D-bol which will result in liver toxicity if used long-term.

When should I take a break from the cycle?

It’s recommended not to use Primobolan Depot for more than 6 weeks in a row; although, you can certainly take multiple breaks throughout the year. Any time you’re on cycle with steroids, be sure to follow these two rules: First, always have at least one break every 3-6 months of using anabolics regardless of which ones they are—otherwise your body will not have any chance to recover from them! Secondly, whenever stacking several compounds together, never go over 6 weeks on an all-inclusive basis when adding another oral steroid. Remember too that there are many milder non-aromatizing orals out there so consider this before running Anadrol or Dianabol exclusively.

Can women use it?

Can women use it?

Yes, women can use Primobolan Depot safely. As mentioned above, Primo stacks well with Trenbolone and Testosterone for cutting cycles as it doesn’t aromatize or cause many of the typical feminizing side effects that some testosterone do—like excess hair growth. In fact, some female bodybuilders consider stacking Primo with Winstrol during contest prep as a means to “lean out” while avoiding the masculinizing side effects of stronger steroids like Equipoise or Anadrol. Furthermore, it’s also a great steroid to stack with Masteron if you’re a woman who needs to lean out without losing too much size—Masteron being a mild anabolic and low androgenic compound which won’t adversely affect muscle tissue to a great degree. Of course, because it’s not anabolics like Trenbolone or Masteron that’ll cause the bulk of water retention or gynecomastia (female breast-growth), you’ll still have to watch out for other steroids in your stack if stacking Primo with them.

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What is its best use?

As mentioned above, Primobolan Depot is good for bulking phases where more calories are needed but individuals don’t want to risk excess body fat. It can also be useful during cutting cycles when wanting to retain lean tissue and strength without adding too much size or sacrificing conditioning. However, this steroid can be used during all parts of the bodybuilding cycle so long as you follow the rules of use.

Are there any special precautions?

Like most steroids, if you have pre-existing medical conditions such as high blood pressure or cholesterol, liver disease, kidney disease, diabetes, etc., you should avoid using this or any steroid unless cleared by your physician first due to the stress steroid use can put on these systems. Also, it’s not recommended to stack Primobolan Depot with multiple steroids at once for the same reason. Furthermore, avoid using if you are a woman who is pregnant or nursing—this steroid itself can harm your unborn child and cause breast growth in females.

How can we optimize the Primobolan cycle for muscle growth and fat loss?

Many athletes may be surprised to learn that you can enjoy strong gains using Primo for only 6 weeks of use—and some prefer this short course at higher dosages to get the most out of it. For example, some strength-focused athletes may want to stack with Testosterone or an oral steroid like Dianabol/D-bol for heavier weight training while bulking. However, if you’re more involved in moderately paced workouts and plan on cutting down sometime soon, consider stacking Primobolan Depot with Trenbolone for enhanced definition without losing too much size or muscle mass during your cycle. This also goes for female bodybuilders, who likewise should combine Primo with Winstrol for a leaner look while avoiding masculinizing side effects. Like most anabolic steroid cycles it’d be best to stack with a non-aromatizing and mild oral like Anavar, Primobolan Depot, or Winstrol for a cleaner overall effect on your body’s chemistry which can promote more effective fat loss while preserving lean tissue during cutting cycles.

Lastly, keep in mind that you will have to take breaks from the use of this compound if running long courses as it is 17-alpha alkylated and not recommended for longer than 6 weeks of continuous use at any dose. In fact, many prefer to limit their total course duration to no more than 8 weeks of total use going forward—and some have even reported good results using the drug only 4 weeks out of a complete 8-week cycle. In any case, those using this steroid for the first time should be aware of its mild nature and not plan on going overboard with dosing as it may have a negative impact on side-effect/risk factors if used improperly.

Do you need a PCT plan after your Primo cycle?

If running a moderate course of Primobolan Depot, then no post-cycle therapy is necessary—simply run blood work during the course to monitor organ health. However, many athletes prefer to use N2Guard after their cycles regardless of how long they ran steroids simply because steroids can put stress on organs even when used responsibly by healthy adults without pre-existing medical conditions—and also because it’s inexpensive compared to most PCT products. This PCT plan will also help to combat high blood pressure and cholesterol levels which can result from steroid use, making post-cycle therapy with N2Guard a wise choice for overall health purposes in addition to organ protection.

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Time To End My Primobolan Cycle

How do I know when it’s time to end my Primobolan cycle?

Generally speaking, 8-12 weeks is the preferred course length with this anabolic steroid by most athletes who prefer shorter courses—and typically 8 weeks at higher doses is more than enough for all but the most advanced users. However, if you’re stacking with other medium/long ester-based steroids like Equipoise or Trenbolone then 12-week courses are not unheard of among experienced athletes. Regardless of how long you plan to use Primobolan Depot, the rule of thumb is that you should discontinue use when your body’s natural testosterone production starts to shut down. If this happens, then it may be time to end the cycle and get blood work done for TC, Testosterone, LH/FSH, and estrogen levels before moving onto a PCT protocol like N2Guard as outlined above.

How do I run Primobolan Depot correctly?

The standard dosage range for healthy adult men is 200-600mg per week, with 400mg per week being an average course length among athletes at this level. For female users we recommend starting with 50-100mg per week and ramping up slowly over time if needed—many women tend to do best on something like 100mg every other week. However, as with all anabolic steroid use, everyone is different and each individual may respond differently to doses even at the same level so there’s no substitute for careful observation and properly tracking one’s own results as they go. Remember that Primobolan Depot is a 17-alpha alkylated compound and therefore liver values should be carefully monitored during use to avoid any complications or damage due to oxidative stress.

Is Primobolan the right choice for you?

To answer this question we turn once again to consider your goals: if you’re looking for a mild anabolic steroid with low side effects and few risks then yes, it would make a solid choice—especially if you stack it with another medium/long ester based steroid like Equipoise or Trenbolone. However, it’s important to remember that total dosing for a given course is really a secondary concern compared to the steroids being used as part of your stack. In other words, if you have 200mg per week of Primobolan Depot and 100mg per week of Sustanon, then that’s 400mg per week overall even though only 200mg is coming from Primo itself. If that same individual were taking 400mg per week of Primo and 800mg per week of Sustanon, then their total dose would be 1,200 but all of it would be coming from short-ester-based compounds.


Primobolan Depot is a mild anabolic steroid that’s been popular with athletes for many decades due to its low androgenic properties, low side effect profile, and ability to produce solid results even at relatively low doses. It can be used as part of a bulking stack or cutting cycle depending on one’s goals, or by itself as a beginner level steroid among lighter weight class athletes—but regardless of how you use it there are some important things to remember:

Be aware of your total dose – stacking short ester based steroids with long ester base steroids is the most common mistake made by new users

If stacking multiple compounds from different families then know that Primobolan Depot is always the “weakest” compound being used so allow for this when planning your total dose

Be aware of how long you use Primobolan Depot because it typically cannot be used for very long periods of time and this is why:

Once your body’s natural testosterone production starts to shut down following the end of a course then it’s time to stop using Primobolan Depot or any other anabolic steroid. If this happens, then it may be time to consider something like N2Guard as outlined above in order to avoid potential damage due to elevated estrogen levels.